Lady, a Cocker Spaniel, was spending a suspicious amount of time down by the backyard pond. "Lady would wander the area, disoriented and withdrawn, soporific and glassy-eyed," Laura Mirsch, Lady's owner, told NPR. Then there was that one night when Lady wouldn't come back. Eventually, she staggered back from the cattails and opened her mouth like she was going to throw up. She didn't throw up. Instead, recalls Mirsch, "out popped this disgusting toad." The toad was Bufo alvarius, a Colorado River toad whose skin contains two different tryptamines—the same psychoactive found in "magic mushrooms"—and licking Bufo produces heady hallucinations.